Reducing the burden of stroke: Opportunities and mechanisms

In this video we describe a step-by-step protocol to study exertional heat stroke (EHS) in a mouse...

Opportunity cost refers to the value of the next best alternative that must be forgone when making a decision. It represents the potential benefits or opportunities sacrificed when choosing one option over another. Understanding opportunity cost is essential in decision-making as it helps individuals, businesses, and societies assess the true cost of their choices.
In life, every decision involves trade-offs, where opting for one alternative means giving up another. For example, pursuing higher...

Here we describe a protocol to determine pulmonary fungal burden in mice with invasive aspergillosis by quantification of Gomori's modified methanamine silver staining in histological sections. Use of this method resulted in comparable results with less animals compared to assessment of fungal burden by quantitative PCR of lung fungal...

This article presents a protocol for executing the highly translational and independently proven mouse Stroke Unit (mSU) concept in large-stroke mice. It also provides a standardized protocol for executing the focal experimental stroke scale in mice, which evaluates stroke focal deficits detected even long-term.

Sunk costs are expenditures already made and cannot be recovered, irrespective of future choices. These costs are essentially "sunk" because they are irretrievable and should not influence future decision-making. On the contrary, opportunity costs denote the value of the best alternative forgone when a decision is taken.
For example, if a company invests in a failing project, the money already spent on it is considered a sunk cost. However, the opportunity cost of continuing with the...

Described here is the photothrombotic stroke model, where a stroke is produced through the intact skull by inducing permanent microvascular occlusion using laser illumination after administration of a photosensitive...