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Updated: Jan 19, 2026

Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies
Published on: November 5, 2016
Neonatal Cardiac ECMO in 2019 and Beyond.
Peter Paul Roeleveld1, Malaika Mendonca2
1Pediatric Intensive Care, Leiden University Medical Center, Leiden, Netherlands.
Extracorporeal Membrane Oxygenation (ECMO) is increasingly used for neonatal cardiac failure, offering a bridge to recovery or transplantation. Survival rates are around 40%, with outcomes influenced by patient selection and supportive care.
Area of Science:
- Pediatrics
- Cardiology
- Critical Care Medicine
Background:
- Extracorporeal Membrane Oxygenation (ECMO) use is rising in neonates with cardiac failure.
- It serves as a crucial bridge to recovery, transplant, or mechanical support for severe heart conditions.
- Neonatal cardiac ECMO is vital for congenital and medical heart diseases, including post-operative stabilization.
Purpose of the Study:
- To review indications, patient selection, and timing for neonatal cardiac ECMO.
- To compare peripheral versus central cannulation strategies.
- To identify predictors of mortality and survival, and discuss supportive care.
Main Methods:
- This is a review article synthesizing current knowledge on neonatal cardiac ECMO.
- It discusses patient selection criteria and cannulation techniques.
- It examines factors influencing outcomes and supportive care strategies.
Main Results:
- Hospital survival for neonatal cardiac ECMO is approximately 40%.
- Outcomes are heavily dependent on the specific indication for ECMO.
- Predictors of mortality and survival are discussed, alongside supportive care insights.
Conclusions:
- Neonatal cardiac ECMO is an established therapy for severe heart failure.
- Careful patient selection, optimal timing, and cannulation strategies are critical for improving survival.
- Long-term neurodevelopmental outcomes require further investigation.
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