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Updated: Jan 19, 2026
The Application of Open Searching-based Approaches for the Identification of Acinetobacter baumannii O-linked Glycopeptides
Published on: November 2, 2021
Site-Selective Esterifications of Polyol β-Hydroxyamides and Applications to Serine-Selective Glycopeptide
Kohei Takemoto1, Yasuhiro Nishikawa1, Shohei Moriguchi1
1Faculty of Pharmacy , Meijo University , 150 Yagotoyama, Tempaku-ku , Nagoya , Aichi 468-8503 , Japan.
Abstract:
The site-selective acylations of β-hydroxyamides in the presence of other hydroxyl groups are described. Central to the success of this modification is the metal-template-driven acylation using pyridine ketoxime esters as acylating reagents in combination with CuOTf. This strategy enables β-hydroxyl groups to be site-selectively acylated in various derivatives, including sterically hindered secondary β-alcohol. The utility of this methodology is showcased by the serine-selective modification of a glycopeptide with unprotected sugar.
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