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Updated: Jan 19, 2026

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
Published on: September 29, 2011
Equivalences between age structured models and state dependent distributed delay differential equations
Tyler Cassidy1, Morgan Craig2,3, Antony R Humphries1,3
1Department of Mathematics and Statistics, McGill University, 805 Sherbrooke Street West, Montréal, H3A 0B9, Canada.
Abstract:
We use the McKendrick equation with variable ageing rate and randomly distributed mat-uration time to derive a state dependent distributed delay differential equation. We show that the resulting delay differential equation preserves non-negativity of initial conditions and we characterise local stability of equilibria. By specifying the distribution of maturation age, we recover state depen-dent discrete, uniform and gamma distributed delay differential equations. We show how to reduce the uniform case to a system of state dependent discrete delay equations and the gamma distributed case to a system of ordinary differential equations. To illustrate the benefits of these reductions, we convert previously published transit compartment models into equivalent distributed delay differential equations.
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