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Updated: Jan 19, 2026

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Direct-write and sacrifice-based techniques for vasculatures.

Shuai Li1, Kan Wang2, Qingxi Hu3

  • 1Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA 30332, USA; Rapid Manufacturing Engineering Center, School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China.

Materials Science & Engineering. C, Materials for Biological Applications
|September 11, 2019
PubMed
Summary
This summary is machine-generated.

Fabricating tissue-engineering vasculatures (TEVs) is challenging. This review compares direct-write and sacrifice-based methods, highlighting their performance, challenges, and future directions for TEVs.

Keywords:
Additive manufacturingDirect-writeSacrifice-based techniqueVasculature

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Fabricating complex, multi-scale biomimetic vasculatures is a significant hurdle in tissue regeneration.
  • Tissue-engineering vasculatures (TEVs) aim to replace native vascular networks.

Purpose of the Study:

  • To review and compare two leading additive manufacturing (AM) techniques for TEVs: direct-write and sacrifice-based methods.
  • To analyze the performance, advantages, and limitations of each fabrication technique.

Main Methods:

  • Focuses on direct-write techniques for fabricating TEVs.
  • Examines sacrifice-based methods utilizing sacrificial templates to create vascular cavities.

Main Results:

  • Direct-write methods offer precise fabrication of complex TEVs.
  • Sacrifice-based techniques enable the formation of desired vascular-like structures through template removal.

Conclusions:

  • Both direct-write and sacrifice-based methods show promise for TEV fabrication.
  • Identifies current challenges and proposes future research directions for next-generation TEVs.