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Updated: Jan 19, 2026
Analysis of DNA Double-strand Break DSB Repair in Mammalian Cells
Published on: September 8, 2010
How Cells Handle DNA Breaks during Mitosis: Detection, Signaling, Repair, and Fate Choice
Ruth Thompson1, Rachel Gatenby2, Samuel Sidi3,4,5
1Department of Oncology and Metabolism, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK. R.H.Thompson@sheffield.ac.uk.
Abstract:
Mitosis is controlled by a complex series of signaling pathways but mitotic control following DNA damage remains poorly understood. Effective DNA damage sensing and repair is integral to survival but is largely thought to occur primarily in interphase and be repressed during mitosis due to the risk of telomere fusion. There is, however, increasing evidence to suggest tight control of mitotic progression in the incidence of DNA damage, whether induced in mitotic cells or having progressed from failed interphase checkpoints. Here we will discuss what is known to date about signaling pathways controlling mitotic progression and resulting cell fate in the incidence of mitotic DNA damage.
Insights
DNA damage during mitosis is tightly controlled by signaling pathways, influencing cell fate. Understanding these mechanisms is crucial for cell survival and cancer research.
Area of Science:
- Cell Biology
- Molecular Biology
- Genetics
Background:
- Mitosis regulation involves complex signaling pathways.
- DNA damage sensing and repair are vital for survival.
- Mitotic control following DNA damage is poorly understood, with potential risks like telomere fusion.
Purpose of the Study:
- To discuss current knowledge on signaling pathways controlling mitotic progression after DNA damage.
- To explore the resulting cell fate in the context of mitotic DNA damage.
Main Methods:
- Literature review of signaling pathways involved in mitotic DNA damage response.
- Analysis of evidence for mitotic control despite DNA damage.
- Discussion of cell fate determination following mitotic DNA damage.
Main Results:
- Increasing evidence suggests tight control of mitotic progression when DNA damage occurs during mitosis.
- Signaling pathways play a critical role in managing DNA damage during mitosis.
- Cell fate is significantly influenced by the response to mitotic DNA damage.
Conclusions:
- Mitotic DNA damage is actively sensed and managed through specific signaling pathways.
- Understanding these pathways is key to comprehending cell survival and potential therapeutic targets in diseases like cancer.
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