Choroid plexus perfusion and intracranial cerebrospinal fluid changes after angiogenesis

Area of Science:

• Neuroscience
• Cerebrovascular Medicine
• Radiology

Background:

• Cortical brain ischemia may impact choroid plexus function via cerebrospinal fluid (CSF) circulation or the glymphatic pathway.
• Neoangiogenesis following revascularization surgery may alter intracranial CSF volume and choroid plexus perfusion.

Purpose of the Study:

• To investigate if improved arterial health post-neoangiogenesis affects intracranial CSF volume and choroid plexus perfusion in humans.
• To explore the relationship between arterial health, paravascular flow, ischemia, and choroid plexus perfusion.

Main Methods:

• Utilized T1-weighted MRI for CSF and tissue volume measurements.
• Employed perfusion-weighted arterial spin labeling MRI for cortical and choroid plexus perfusion assessment.
• Analyzed data from patients undergoing indirect surgical revascularization (n=23) and a control cohort (n=10) at two time points.

Main Results:

• No significant changes in CSF or tissue volumes were observed post-surgery.
• Surgical patients showed increased cortical perfusion and decreased choroid plexus perfusion post-operation.
• Control participants exhibited reduced cortical perfusion and increased choroid plexus perfusion between time points.

Conclusions:

• Findings suggest a homeostatic mechanism where arterial health influences choroid plexus perfusion.
• Changes in paravascular flow and/or ischemia may play a role in regulating choroid plexus perfusion.
• The study provides insights into the interplay between cerebrovascular health and CSF dynamics.