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Updated: Jan 19, 2026

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
Published on: November 8, 2011
Epstein-Barr virus infection in gliomas
S Limam1, N Missaoui2, S Mestiri1
1Pathology Department, Farhet Hached University Hospital of Sousse, 4000 Sousse, Tunisia.
Epstein-Barr virus (EBV) was found in 21.4% of gliomas in Tunisian patients, particularly in glioblastoma multiforme (GBM). EBV-positive GBM patients had a worse prognosis, suggesting EBV
Area of Science:
- Neuro-oncology
- Virology
- Cancer research
Background:
- Epstein-Barr virus (EBV) is linked to certain cancers.
- Its role in glioma development is unclear.
- This study examines EBV in Tunisian glioma patients.
Purpose of the Study:
- Investigate EBV presence in gliomas.
- Analyze the association between EBV and glioma characteristics.
- Determine EBV's impact on patient survival.
Main Methods:
- Retrospective analysis of 112 gliomas.
- EBV DNA detection via PCR.
- LMP1 and EBER detection using immunohistochemistry and in situ hybridization.
- Survival analysis using Kaplan-Meier and Log-Rank tests.
Main Results:
- EBV detected in 21.4% of gliomas (24/112).
- All EBV-positive cases were glioblastoma multiforme (GBM).
- EBV-positive GBM patients showed significantly worse overall and recurrence-free survival.
Conclusions:
- EBV infection occurs in Tunisian GBM.
- EBV positivity is associated with poorer prognosis in GBM.
- Further molecular studies are needed to confirm EBV's role in GBM.
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