Related Experiment Video
Updated: Jan 19, 2026

Direct Reprogramming of Mouse Fibroblasts into Melanocytes
Published on: August 27, 2021
Deconstructing age reprogramming
Prim B Singh1, Petr P Laktionov, Andrew G Newman
1Nazarbayev University School of Medicine, Z05K4F4 Astana, Kazakhstan.
Abstract:
It has been proposed that age reprogramming enables old cells to be rejuvenated without passage through an embryonic stage (Singh and Zacouto in J. Biosci. 35 315-319, 2010). As such, age reprogramming stands apart from the induced pluripotent stem (iPS) and nuclear transfer-embryonic stem (NT-ES) cell therapies where histo-compatible cells are produced only after passage through an embryonic stage. It avoids many of the disadvantages associated with iPS and NT-ES cell therapies. Experimental evidence in support of age reprogramming is burgeoning. Here, we discuss possible new approaches to enhance age reprogramming, which will have considerable benefits for regenerative therapies.
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