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Microfluidics in Assessing Platelet Function
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Platelet function in lung cancer patients undergoing lobectomy.

Anne-Mette Hvas1, Henrik Vad2,3, Søren Pedersen3,4

  • 1Department of Clinical Biochemistry & Institute of Clinical Medicine, Aarhus University Hospital , Aarhus N , Denmark.

Scandinavian Journal of Clinical and Laboratory Investigation
|September 11, 2019
PubMed
Summary

Platelet aggregation is significantly increased in lung cancer patients before surgery. Postoperative platelet aggregation rises in VATS patients but does not differ between VATS and thoracotomy groups.

Keywords:
Platelet aggregationhaemostasislung cancerneoplasmsurgery

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Area of Science:

  • Oncology
  • Hematology
  • Cardiovascular Medicine

Background:

  • Arterial thromboembolic disease is a growing concern in cancer patients.
  • Platelets play a crucial role in thromboembolic events, necessitating investigation in cancer settings.
  • Lung cancer surgery presents a unique context to study platelet behavior.

Purpose of the Study:

  • To investigate platelet aggregation in lung cancer patients undergoing surgery.
  • To compare platelet aggregation between video-assisted thoracoscopic surgery (VATS) and thoracotomy procedures.
  • To assess changes in platelet aggregation from pre-surgery to post-surgery.

Main Methods:

  • Prospective study of 93 lung cancer patients (VATS and thoracotomy groups).
  • Platelet aggregation analyzed using impedance aggregometry with ADP and collagen agonists.
  • Comparison with 121 healthy individuals pre-surgery and serial measurements post-surgery.

Main Results:

  • Pre-surgery: Significantly increased platelet aggregation in both VATS and thoracotomy patients compared to healthy controls.
  • Pre-surgery: No significant difference in platelet aggregation between VATS and thoracotomy patients.
  • Post-surgery (Day 1): VATS patients showed increased collagen-induced platelet aggregation compared to pre-surgery levels.
  • Post-surgery (Day 2): Thoracotomy patients showed reduced platelet aggregation compared to pre-surgery levels.

Conclusions:

  • Primary lung cancer is associated with significantly increased platelet aggregation even before surgery.
  • Surgical approach (VATS vs. thoracotomy) does not significantly alter the pattern of platelet aggregation increase on postoperative day one.
  • Platelet aggregation dynamics differ between VATS and thoracotomy patients in the early postoperative period.