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Outpatient parenteral antimicrobial therapy: updated recommendations from the UK

Ann L N Chapman1, Sanjay Patel2, Carolyne Horner3

  • 1University Hospital Monklands, NHS Lanarkshire, Airdrie, UK.

The Journal of Antimicrobial Chemotherapy
|September 11, 2019
PubMed

Insights

Updated UK guidelines enhance outpatient parenteral antimicrobial therapy (OPAT) for adults and children. Key changes address new antimicrobials, oral alternatives, service models, and antimicrobial stewardship.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Healthcare Management

Background:

  • Outpatient parenteral antimicrobial therapy (OPAT) provides safe and effective patient-centered care.
  • Recent advancements necessitate updated OPAT guidelines.
  • Existing recommendations required revision to incorporate new developments.

Purpose of the Study:

  • To discuss key changes in the updated OPAT UK good practice recommendations.
  • To contextualize these changes within recent developments in antimicrobial therapy.
  • To highlight advancements relevant to OPAT services for adults and children.

Main Methods:

  • Literature review of recent antimicrobial research and OPAT practices.
  • Expert consensus on best practices for OPAT.
  • Extensive stakeholder consultation to refine recommendations.

Main Results:

  • Updated recommendations incorporate novel antimicrobial agents and delivery devices.
  • The role of oral antimicrobials as an alternative to intravenous therapy is clarified.
  • New OPAT service models and integration with antimicrobial stewardship are addressed.

Conclusions:

  • The updated OPAT UK recommendations reflect current best practices.
  • These guidelines support safe, effective, and patient-centered OPAT.
  • The changes aim to optimize antimicrobial use and patient outcomes in OPAT settings.

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