[The analysis of content of lymphocytes carrying adhesion molecules in patients with psoriasis.]

The study of mechanisms of migration activity of lymphocytes into skin under psoriasis represents both theoretical and practical interest because regulation of the given process provides new possibility in therapy. As is well known, process of migration of lymphocytes through endothelium of micro-circulation is regulated by molecules of adhesion. The study was carried out to detect content of lymphocytes expressing molecules of adhesion depending on their morphology. The study was implemented in 82 patients with vulgar and exudative psoriasis at progressing and stationary stages (39 females and 43 males out of total number) aged from 20 to 60 years. The control group consisted of 50 healthy individuals (28 females and 22 males). The lymphocytogram was analyzed alongside with detection of content of lymphocytes expressing receptors to molecules of adhesion in venous blood. The content of minor lymphocytes had no alteration in condition of hyper-proliferation of keratinocytes. This occurrence is typical for psoriasis. In patients with psoriasis, no alteration of concentration of medium lymphocytes was detected. Under psoriasis, intensified migration of large lymphocytes from peripheral blood is observed testified by decreasing of their absolute number and statistically reliable correlations with content of lymphocytes expressing receptors to LFA-1, LFA-3, ICAM-1 и PECAM-1.