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[Infection factors associated with neurodysplasia in early and moderately preterm infants]
Qin Chang1, Bin Hu, Cheng-Ju Wang
1Department of Pediatrics, Second Affiliated Hospital of Army Medical University, Chongqing 400037, China. 465616386@qq.com.
Insights
Late-onset infections increase the risk of neurodevelopmental disorders (neurodysplasia) in preterm infants. This study identified late-onset infection as a key factor impacting neurodevelopmental outcomes at 18 months corrected age.
Area of Science:
- Neonatal Medicine
- Developmental Pediatrics
- Infectious Diseases
Background:
- Preterm infants are susceptible to neurodevelopmental impairments.
- Neurodysplasia is a significant concern in early and moderately preterm infants.
- Identifying infection-related risk factors is crucial for early intervention.
Purpose of the Study:
- To examine infection-related factors associated with neurodysplasia in preterm infants.
- To assess neurodevelopmental outcomes at 18 months corrected age.
- To identify specific infections that pose a risk.
Main Methods:
- Study included 138 preterm infants (28 to <34 weeks gestational age).
- Neurodevelopment evaluated using the revised Bayley Scales of Infant Development at 18 months corrected age.
- Logistic regression analyses (univariate and multivariate) used to identify infection factors.
Main Results:
- 59 out of 138 infants exhibited neurodysplasia at 18 months corrected age.
- Univariate analysis linked neurodysplasia to late-onset infection and positive blood cultures.
- Multivariate analysis confirmed late-onset infection as an independent risk factor (OR=1.510, P<0.05).
Conclusions:
- Late-onset infection is a significant risk factor for neurodysplasia in preterm infants.
- Early identification and management of late-onset infections are vital.
- Findings highlight the importance of monitoring neurodevelopment in high-risk preterm populations.
Objective:
To investigate the infection factors associated with neurodysplasia in early and moderately preterm infants at a corrected age of 18 months.
Methods:
The preterm infants with a gestational age of 28 weeks to <34 weeks who were admitted to the neonatal intensive care unit and followed up at the outpatient service for high-risk preterm infants from June 2015 to December 2018 were enrolled as subjects. At a corrected age of 18 months, the revised Bayley Scales of Infant Development was used to evaluate neurodevelopment. Univariate and multivariate logistic regression analyses were used to investigate the infection factors affecting neurodevelopment.
Results:
A total of 138 early or moderately preterm infants were enrolled, among whom 59 had neurodysplasia at a corrected age of 18 months. The univariate logistic regression analysis showed that neurodysplasia was associated with late-onset infection, positive blood culture, and other systemic infections (P<0.05). The multivariate logistic regression analysis showed that late-onset infection was an independent risk factor for neurodysplasia (OR=1.510, 95%CI: 1.133-3.600, P<0.05).
Conclusions:
Late-onset infection can increase the risk of neurodysplasia in early and moderately preterm infants.
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