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[Serum level of soluble transferrin receptor in children with hemoglobin H disease]

Zhen-Min Ren1, Li-Lan Huang, Bao-Xing Huang

  • 1Department of Laboratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, China. chenyunsheng66@163.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|September 12, 2019
PubMed

Insights

Serum soluble transferrin receptor (sTfR) levels correlate with anemia severity in children with hemoglobin H (HbH) disease. Elevated sTfR suggests its potential as a therapeutic target for HbH anemia.

Area of Science:

  • Hematology
  • Pediatric Medicine
  • Genetic Blood Disorders

Background:

  • Hemoglobin H (HbH) disease is a form of alpha-thalassemia characterized by anemia.
  • Soluble transferrin receptor (sTfR) is a marker of erythropoiesis and iron status.

Purpose of the Study:

  • To investigate serum sTfR levels in children with HbH disease.
  • To assess the association between serum sTfR and the degree of anemia in pediatric HbH disease.

Main Methods:

  • Retrospective analysis of 55 children with HbH disease and 30 healthy controls.
  • HbH group divided into deletional and non-deletional subtypes.
  • Measured hematological parameters and serum sTfR levels.

Main Results:

  • Children with HbH disease exhibited lower hemoglobin, MCV, and MCH, and higher sTfR compared to controls.
  • Non-deletional HbH disease showed lower RBC and Hb, but higher MCV, MCH, and sTfR than deletional HbH disease.
  • Serum sTfR levels were negatively correlated with RBC and Hb, and positively with MCV and MCH in HbH disease.

Conclusions:

  • Serum sTfR levels are significantly associated with the degree of anemia in pediatric HbH disease.
  • sTfR may serve as a valuable biomarker for anemia severity in HbH disease.
  • sTfR presents a potential therapeutic target for managing anemia in HbH disease.
Abstract

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