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Updated: Jan 19, 2026
Disrupting Reconsolidation of Fear Memory in Humans by a Noradrenergic β-Blocker
Published on: December 18, 2014
On the Involvement of BDNF Signaling in Memory Reconsolidation
Maria Carolina Gonzalez1, Andressa Radiske1, Martín Cammarota1
1Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
Abstract:
When retrieval occurs concomitantly with novelty detection, mismatch perception or reactivation of conflicting information, consolidated memories can enter into a labile state, and to persist, must be restabilized through a protein synthesis-dependent reconsolidation process during which their strength and content can be modified. Extensive literature implicates brain-derived neurotrophic factor (BDNF), a key regulator of synaptogenesis and synaptic plasticity, in the acquisition, consolidation and extinction of several memory types. However, the participation of BDNF in memory reconsolidation has been less studied. In this review, we discuss recent reports supporting the involvement of BDNF signaling in reactivation-induced memory updating.
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