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Related Experiment Video

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Imaging modalities aiding nerve-sparing during radical prostatectomy.

Adil Jaulim1, Abdüllatif Aydın2,3, Farheen Ebrahim4

  • 1Cancer Research UK Cambridge Institute, University of Cambridge; Department of Urology, Addenbrooke's Hospital, Cambridge, UK.

Turkish Journal of Urology
|September 12, 2019
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Summary

Multiphoton microscopy (MPM) offers high-resolution, deep imaging for nerve-sparing prostatectomy, potentially improving surgical outcomes. Dual-modality MPM may overcome current limitations for future surgical applications.

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Area of Science:

  • Urology
  • Surgical Oncology
  • Medical Imaging

Background:

  • Robot-assisted radical prostatectomy (RARP) improves outcomes but doesn't eliminate post-surgical complications.
  • Enhanced visualization of surgical site microstructures can guide better surgical decisions.
  • Current imaging modalities have limitations in speed, cost, resolution, and depth for intraoperative use.

Purpose of the Study:

  • To review and compare multiphoton microscopy (MPM), optical coherence tomography (OCT), and confocal microscopy (CM) for potential application in nerve-sparing radical prostatectomy.
  • To identify the optimal imaging technique for improved surgical precision and patient outcomes.

Main Methods:

  • Literature review using Embase and Medline databases.
  • Keywords included "Radical prostatectomy," "nerve-sparing," "nerve mapping," "multiphoton microscopy," "Confocal microscopy," and "Optical Coherence Tomography."
  • Selection and analysis of relevant studies comparing the specified microscopy techniques.

Main Results:

  • Optical coherence tomography (OCT) is low-cost and compact but lacks cellular resolution.
  • Confocal microscopy (CM) provides excellent cellular resolution but limited imaging depth.
  • Multiphoton microscopy (MPM) offers high-resolution imaging with sufficient depth for surgical applications.

Conclusions:

  • Multiphoton microscopy (MPM) shows promise for intraoperative nerve mapping during radical prostatectomy due to its imaging capabilities.
  • Limitations of MPM include lack of portability, but dual-modality systems may offer a future solution.
  • Advancements in imaging technology are crucial for improving nerve-sparing surgical techniques and patient recovery.