Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Frailty Assessment in an Aging Mouse Model06:58

Frailty Assessment in an Aging Mouse Model

438
The goal of the present protocol is to provide instructions and guidelines for assessing physical frailty in C57Bl/6x129J laboratory mice. Specific details regarding each measure used in the physical frailty index are explained. Several methods for reporting frailty results are also...
438
Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment04:00

Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment

1.2K
Here, we present a protocol to assess frailty in the perioperative setting using point-of-care ultrasound to measure quadriceps thickness. This method offers a practical, non-invasive alternative to traditional assessment methods, potentially enhancing perioperative care by quickly identifying frail...
1.2K
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

17.0K
Frailty syndrome is commonly seen in the aged and reflects multi-system physiological change. However, with reduced functional reserve and resilience frailty is also known to be common in the HIV infected population. This study outlined an easily administered screening test to identify HIV patients with frailty. When significant components of frailty are identified, clinicians will be able to focus on amelioration of the problem and promote reversion to the pre-frail...
17.0K
Low-Cost Gait Analysis for Behavioral Phenotyping of Mouse Models of Neuromuscular Disease05:53

Low-Cost Gait Analysis for Behavioral Phenotyping of Mouse Models of Neuromuscular Disease

17.6K
Footprint analysis is a low-cost alternative to digitized gait analysis programs for researchers quantifying movement abnormalities in mice. Because of its speed, simplicity, and longitudinal potential, it is ideal for behavioral phenotyping of mouse...
17.6K
Tuina Intervention in Rabbit Model of Knee Osteoarthritis04:23

Tuina Intervention in Rabbit Model of Knee Osteoarthritis

2.1K
The protocol describes a method for Tuina intervention in a rabbit model of knee...
2.1K
Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

17.1K
Anti-retroviral therapy to treat HIV/AIDS is monitored in South Africa on a large scale. Flow cytometry is combined for haematology (CD45), immunology (CD4) and viral-load linked CD38 assay. Recorded at NHLS-SA laboratories, Johannesburg, these modern methods are cost-efficient with heightened local internal quality control, serving as role-models for resource-limited...
17.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Model-Based Cost-Effectiveness Analysis of Routine Omega-3 Testing and Targeted Supplementation to Reduce Early Preterm Birth in Australia Compared with Current Practice.

ClinicoEconomics and outcomes research : CEOR·2026
Same author

Developing a patient reported measure on out-of-pocket healthcare expenditure among Aboriginal patients: a formative study.

Health promotion international·2026
Same author

Trend and cost analysis comparing laparoscopic versus open liver resections at a Tertiary Referral hospital in Australia.

Surgery in practice and science·2026
Same author

Lowering the Barriers to the Appropriate Use of Individual-Level Simulation for Health Economic Evaluation.

PharmacoEconomics·2026
Same author

Health Literacy-Focused Communication Training for Primary Healthcare Providers Working With Older Adults: A Co-Designed Prototype.

Health expectations : an international journal of public participation in health care and health policy·2026
Same author

Evaluating Cost-Effectiveness of 85 Endoscopic Surveillance Strategies of Nondysplastic Barrett's Esophagus.

Journal of gastroenterology and hepatology·2026

Related Experiment Video

Updated: Jan 19, 2026

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

438

Structuring a conceptual model for cost-effectiveness analysis of frailty interventions.

Hossein Haji Ali Afzali1, Jonathan Karnon1, Olga Theou2

  • 1College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.

Plos One
|September 12, 2019
PubMed
Summary

This study presents a conceptual model for frailty interventions, crucial for economic evaluations and public funding decisions. It identifies key health states and patient attributes to improve cost-effectiveness modeling for older adults.

More Related Videos

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.2K
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

17.0K

Related Experiment Videos

Last Updated: Jan 19, 2026

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

438
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.2K
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

17.0K

Area of Science:

  • Gerontology
  • Health Economics
  • Epidemiology

Background:

  • Frailty significantly impacts older adults and presents a major challenge to healthcare systems.
  • Developing interventions to halt or reverse frailty progression is a key emerging area.
  • Economic evidence and cost-effectiveness models are essential for public funding decisions regarding frailty interventions.

Purpose of the Study:

  • To present a conceptual model of frailty.
  • To inform the development of a cost-effectiveness model for evaluating frailty interventions.
  • To improve transparency and accuracy in modeling the long-term costs and effects of frailty interventions.

Main Methods:

  • Critical analysis of clinical and economic literature.
  • A Delphi study involving clinical medicine and epidemiology experts.
  • Identification of relevant databases for model population and validation.

Main Results:

  • Identified significant health states/events associated with frailty (e.g., hip fracture, hospital admission, delirium, death).
  • Identified important patient attributes influencing frailty progression (e.g., age, gender, prior admissions, depression).
  • Identified large-scale databases for populating and validating the cost-effectiveness model; confirmed face validity with experts.

Conclusions:

  • The conceptual model serves as a foundation for a new cost-effectiveness model to assess lifetime costs and outcomes of frailty interventions.
  • An accurate model structure reflecting frailty's natural history enhances transparency and precision.
  • This improved modeling will support better-informed public funding decisions for frailty management interventions.