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Related Experiment Video

Updated: Jan 19, 2026

Derivation of Mouse Trophoblast Stem Cells from Blastocysts

Derivation of Mouse Trophoblast Stem Cells from Blastocysts

Published on: June 8, 2010

Building Blastocysts from Stem Cells.

Maayan Pour¹, Iftach Nachman¹

¹School of Neurobiology, Biochemistry and Biophysics, Tel Aviv University, Tel Aviv, Israel.

Stem Cell Reports

|September 12, 2019

Summary

Researchers created blastocyst-like structures from pluripotent stem cells. This novel method offers a new tool for studying early embryonic development and implantation, which are crucial for pregnancy.

Area of Science:

Developmental biology
Stem cell research
Reproductive science

Background:

The blastocyst stage and implantation are critical for pregnancy but difficult to study in vivo.
Understanding these early events is key to addressing infertility and pregnancy complications.

Purpose of the Study:

To develop a novel in vitro model of the blastocyst stage using only pluripotent stem cells.
To provide a new tool for investigating early human embryonic development.

Main Methods:

Generation of blastocyst-like structures from pluripotent stem cells.
Characterization of these structures for resemblance to in vivo blastocysts.

Main Results:

Successfully generated blastocyst-like structures from pluripotent stem cells.

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Published on: August 10, 2022

Related Experiment Videos

Last Updated: Jan 19, 2026

Derivation of Mouse Trophoblast Stem Cells from Blastocysts

Derivation of Mouse Trophoblast Stem Cells from Blastocysts

Published on: June 8, 2010

Human Blastocyst Biopsy and Vitrification

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Published on: August 10, 2022

These structures mimic key aspects of the natural blastocyst stage.

Conclusions:

The novel stem cell-derived blastocyst-like structures offer a promising new model for studying early embryonic development.
This tool can advance research into implantation and early pregnancy, overcoming in vivo study limitations.