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The study of active avoidance: A platform for discussion.

Maria M Diehl1, Christian Bravo-Rivera2, Gregory J Quirk3

  • 1Departments of Psychiatry and Anatomy & Neurobiology, University of Puerto Rico School of Medicine, San Juan, PR, 00936, Puerto Rico; Department of Psychological Sciences, Kansas State University, Manhattan, KS, 66506 United States.

Neuroscience and Biobehavioral Reviews
|September 12, 2019
PubMed
Summary
This summary is machine-generated.

Platform-mediated avoidance (PMA) better models clinical avoidance than traditional tasks. This research highlights the role of amygdala-striatal circuits and the prelimbic cortex in avoidance behaviors, suggesting future research directions.

Keywords:
AccumbensAmygdalaFearPrelimbic cortexStriatum

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Cognitive Science

Background:

  • Traditional active avoidance tasks are limited in clinical relevance.
  • These tasks do not fully model key features of clinical avoidance behaviors.

Purpose of the Study:

  • To compare platform-mediated avoidance (PMA) with traditional tasks.
  • To investigate the neural circuits underlying PMA.
  • To explore the role of the prelimbic cortex in avoidance.

Main Methods:

  • Utilized platform-mediated avoidance (PMA) tasks.
  • Examined neuronal circuits involved in avoidance responses.
  • Investigated the function of the prelimbic cortex in PMA.

Main Results:

  • PMA more closely resembles clinical avoidance by including a safe location, avoiding artificial signal termination, and involving decision-based costs.
  • Amygdala-striatal circuits are essential for avoidance behaviors.
  • The prelimbic cortex facilitates early avoidance responses in PMA, potentially via striatal disinhibition.

Conclusions:

  • PMA offers a more clinically relevant model for studying avoidance.
  • Amygdala-striatal pathways and prelimbic cortex are crucial for avoidance.
  • Future research should consider sex differences and social interactions in avoidance studies for neuropsychiatric disorders.