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Updated: Jan 19, 2026

Studying Wnt Signaling During Patterning of Conducting Airways
Published on: October 16, 2016
Wnt ligand and receptor patterning in the liver
Eider Valle-Encinas1, Trevor C Dale1
1Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.
Abstract:
In the liver, the tight spatiotemporal regulation of Wnt/β-catenin signaling is required to establish and maintain a metabolic form of tissue polarity termed zonation. In this review, we discuss the latest technologies applied in the study of liver zonation and provide a summary of the Wnt ligand and receptor expression patterns in the hepatic lobule. We further discuss the mechanisms, by which Wnt instructive cues might be spatially confined and propagated along the central vein-portal triad axis.
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