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Updated: Jan 19, 2026

Three-Dimensional Quantitative Phase Imaging for Characterizing Lymphocyte Subtypes
Full-field quantitative phase and polarisation-resolved imaging through an optical fibre bundle
Researchers developed a new method using multi-core optical fibres (MCF) to image quantitative phase and polarization properties. This technique overcomes limitations of conventional endoscopy, enabling advanced imaging capabilities.
Area of Science:
- Optics and Photonics
- Biomedical Imaging
- Materials Science
Background:
- Conventional flexible optical fibres scramble phase and polarization, limiting imaging to amplitude information.
- This restricts applications in medical endoscopy and industrial inspection.
Purpose of the Study:
- To develop a method for accurate quantitative phase and polarization-resolved imaging using multi-core fibres (MCF).
- To overcome the limitations of amplitude-only imaging in flexible fibre optics.
Main Methods:
- Exploited the near-diagonality of the MCF transmission matrix in a parallelised fibre characterisation architecture.
- Measured and inverted the transmission matrix for accurate recovery of optical amplitude and phase in two polarizations.
- Applied a Bayesian inference approach to resolve 5 polarimetric properties of samples.
Main Results:
- Achieved accurate quantitative phase imaging with errors <0.3 rad.
- Obtained accurate polarization-resolved imaging with errors <10%.
- Generated high-resolution full-field images (9.0±2.6 µm for amplitude/phase, 36.0±10.4 µm for polarimetric) over a 750×750 µm² field-of-view at a 1mm working distance.
Conclusions:
- The developed method enables high-fidelity quantitative phase and polarization imaging through flexible MCFs.
- Demonstrated potential for computational image focusing using quantitative phase.
- Showcased the utility of polarization-resolved imaging for detecting sample birefringence.
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