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Updated: Jan 19, 2026

Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure
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Polymicrobial Cerebral Abscess in a Child with Uncorrected Tetralogy of Fallot

Yusra Shafquat1, Mohammed Zeeshan1, Saeeda Chandio1

  • 1Aga Khan University Hospital, Karachi, Pakistan.

JPMA. the Journal of the Pakistan Medical Association
|September 13, 2019
PubMed

Insights

Aggregatibacter aphrophilus and Beta-hemolytic Streptococci Lancefield group F can cause serious infections like brain abscesses, especially in children with congenital heart disease. Prompt antibiotic treatment with ceftriaxone led to recovery in a young patient with Tetralogy of Fallot.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pediatrics

Background:

  • Aggregatibacter aphrophilus and Beta-hemolytic Streptococci Lancefield group F are commensal oral flora.
  • These bacteria are recognized causes of various infections, including endocarditis, sinusitis, empyema, meningitis, and septic arthritis.

Observation:

  • A 10-year-old boy with Tetralogy of Fallot (TOF) presented with symptoms of fever, headache, and drowsiness.
  • Cranial imaging was not mentioned, but clinical presentation suggested a central nervous system infection.

Findings:

  • Cultures from the patient revealed the presence of both Aggregatibacter aphrophilus and Beta-hemolytic Streptococci Lancefield group F.
  • The patient's clinical condition improved significantly following treatment with ceftriaxone.

Implications:

  • This case highlights the emerging role of Aggregatibacter aphrophilus and Beta-hemolytic Streptococci Lancefield group F in causing brain abscesses.
  • Congenital heart diseases, such as Tetralogy of Fallot, may predispose individuals to these serious infections.
  • Early diagnosis and appropriate antibiotic therapy are crucial for managing brain abscesses caused by these oral pathogens.
Keywords:
Infective endocarditis, tetralogy of Fallot, Aggregatibacter aphrophilus, brain abscess.

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