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Updated: Jan 19, 2026
Isolation and Profiling of MicroRNA-containing Exosomes from Human Bile
Published on: June 13, 2016
A bioinformatics analysis of exosomal microRNAs released following mycobacterial infection
Shamila D Alipoor1, Ian M Adcock2, Gert Folkerts3
1Department of Molecular Medicine, Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Background:
Tuberculosis (TB) still remains a major health threat worldwide. The current TB diagnostics are suboptimal, and there is a high clinical need for identifying novel biomarkers of disease prevalence. Circulating exosomes have been currently attractive as novel biomarkers in a wide range of pathological conditions.
Methods:
In this study, we performed bioinformatics analysis on the downstream targets of a dysregulated microRNA (miRNA) cluster induced by Bacillus Calmette-Guerin infection of human macrophages to provide greater understanding of their potential roles in disease pathogenesis.
Results:
Our analysis demonstrated that these dysregulated miRNAs have central roles in the host metabolic and energy pathways.
Conclusion:
This suggests that the host miRNA network is perturbed by Mycobacterium to re-patterning host metabolism machinery to favor its intracellular survival. The dysregulated miRNAs can be delivered to local and distal cells by exosomes and thereby modulate their function.
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