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Deep Brain Stimulation in Parkinson's Disease.

Naveed Malek1

  • 1Department of Neurology, Ipswich Hospital NHS Trust, United Kingdom.

Neurology India
|September 13, 2019
PubMed
Summary

Deep brain stimulation (DBS) is effective for Parkinson's disease (PD) motor symptoms, even in early stages. While not a cure, DBS offers sustained therapeutic benefits for PD patients.

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Area of Science:

  • Neurology
  • Neurosurgery

Background:

  • Deep brain stimulation (DBS) is a key therapy for advanced Parkinson's disease (PD) with motor complications.
  • The EARLYSTIM trial confirmed DBS efficacy in early PD motor complications, showing sustained benefits over time.

Purpose of the Study:

  • To introduce the technical aspects and evidence base of DBS for movement disorder trainees.
  • To summarize the efficacy of DBS in Parkinson's disease based on existing literature.

Main Methods:

  • A PubMed search was conducted from 1946 to 2017 using "deep brain stimulation" and "Parkinson's disease" keywords.
  • Inclusion criteria: studies with >20 PD patients, physician-confirmed diagnosis, and ≥12 months follow-up.

Main Results:

  • DBS demonstrates efficacy in improving motor symptoms in Parkinson's disease.
  • Studies reviewed indicate positive impacts on medication needs, quality of life, and daily living independence.
  • Sustained therapeutic benefits of DBS for Parkinson's disease were observed.

Conclusions:

  • DBS is an established therapy for managing motor fluctuations and dyskinesias in Parkinson's disease.
  • It's crucial to manage patient expectations, as DBS is not a cure and does not halt disease progression.
Keywords:
Deep brain stimulationParkinson's diseasedyskinesias

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