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Updated: Jan 19, 2026

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants
Published on: August 5, 2021
[Effects of platelet-derived growth factor on nerve regeneration around implant in rats]
Yan-Ying Wang1, Ping Gong2, Jian Zhang1
1Dept. of Implantology, Tianjin Stomatological Hospital; Hospital of Stomatology, Nankai University, Tianjin 300041, China.
Objective:
To investigate the effect of platelet-derived growth factor (PDGF) on nerve regeneration in peri-implant tissues.
Methods:
SD rats with implants in their femurs were injected with PDGF solution. The effects of PDGF on nerve regeneration in peri-implant tissues were analyzed by immunohistochemical staining.
Results:
PDGF increased the number of nerve fibers in peri-implant tissues at early stage. PDGF had no significant effect on the number of nerve fibers in peri-implant tissues at late stage. Moreover, these nerves had a typical structure of peripheral nerve fibers.
Conclusions:
PDGF can promote nerve regeneration in peri-implant tissues at early stage. This study provided a certain experimental basis for the clinical application of PDGF to promote nerve regeneration and further improve the sensory function of the implant.
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