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[Oral manifestations of KID syndrome: rare clinical case]

M V Korolenkova1, N A Dmitrieva1, I I Babichenko1

  • 1Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.

Stomatologiia
|September 13, 2019
PubMed

Insights

This case study highlights a rare Keratitis, Ichthyosis, Deafness (KID) syndrome presentation in a child with oral candidiasis. Dental issues, not just the syndrome, significantly impacted oral health, requiring intervention.

Area of Science:

  • Dermatology
  • Genetics
  • Oral Medicine

Background:

  • Keratitis, Ichthyosis, Deafness (KID) syndrome is a rare genetic disorder affecting skin, eyes, and hearing.
  • Patients with KID syndrome exhibit impaired innate immunity and tissue repair, increasing susceptibility to infections.

Observation:

  • A 4-year-old girl with KID syndrome presented with persistent oral vegetating candidiasis unresponsive to treatment.
  • Oral lesions were found to be exacerbated by sharp, carious teeth.
  • Histological examination of oral biopsies revealed pyogenic granulomas, ruling out squamous cell carcinoma (SCC).

Findings:

  • Dental caries and sharp tooth edges were identified as a primary contributor to the oral mucosal lesions.
  • Histopathology confirmed pyogenic granulomas, not SCC, in the multifocal biopsy.
  • Treatment involving tooth extraction and symptomatic care led to substantial clinical improvement.

Implications:

  • This case underscores the importance of addressing dental health in patients with KID syndrome.
  • Interdisciplinary management, including dental intervention, is crucial for improving quality of life in rare genetic disorders.
  • Early identification of contributing factors, like dental issues, can optimize treatment outcomes for complex conditions.

Keywords:
KID syndromehistological studyoral microbiotaoral mucosa

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