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Conflicting Roles of 20-HETE in Hypertension and Stroke

Shashank Shekhar1, Kevin Varghese2, Man Li3

  • 1Department of Neurology, University of Mississippi Medical Center, Jackson, MS 39216, USA. sshekhar@umc.edu.

International Journal of Molecular Sciences
|September 14, 2019
PubMed

Hypertension is the most common modifiable risk factor for stroke, and understanding the underlying mechanisms of hypertension and hypertension-related stroke is crucial. 20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid (20-HETE), which plays an important role in vasoconstriction, autoregulation, endothelial dysfunction, angiogenesis, inflammation, and blood-brain barrier integrity, has been linked to hypertension and stroke. 20-HETE can promote hypertension by potentiating the vascular response to vasoconstrictors; it also can reduce blood pressure by inhibition of sodium transport in the kidney. The production of 20-HETE is elevated after the onset of both ischemic and hemorrhagic strokes; on the other hand, subjects with genetic variants in CYP4F2 and CYP4A11 that reduce 20-HETE production are more susceptible to stroke. This review summarizes recent genetic variants in CYP4F2, and CYP4A11 influencing 20-HETE production and discusses the role of 20-HETE in hypertension and the susceptibility to the onset, progression, and prognosis of ischemic and hemorrhagic strokes.

Keywords:
angiogenesisblood-brain barriercerebral autoregulationcytochrome P450endothelial dysfunctionhypertensionstrokevascular inflammationvascular remodeling

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