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Related Experiment Video

Updated: Jan 19, 2026

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
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Stage III Non-small Cell Lung Cancer Management in England.

J B Adizie1, A Khakwani2, P Beckett3

  • 1University Hospitals Birmingham, Birmingham, UK.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|September 14, 2019
PubMed
Summary

Optimal care for stage III non-small cell lung cancer (NSCLC) in England is lacking. Less than one-fifth of patients received recommended multimodality treatment, impacting survival rates.

Keywords:
Concurrent chemoradiotherapymultimodality treatmentpopulation-based studystage III NSCLC

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Area of Science:

  • Oncology
  • Public Health

Background:

  • Stage III non-small cell lung cancer (NSCLC) requires complex management strategies.
  • Understanding current treatment patterns and outcomes is crucial for improving patient care.

Purpose of the Study:

  • To analyze the management and outcomes of stage III NSCLC in England.
  • To identify disparities in treatment delivery and survival rates.

Main Methods:

  • Analysis of National Lung Cancer Audit data for 6276 patients diagnosed in 2016.
  • Utilized linked datasets for comprehensive treatment categorization.
  • Kaplan-Meier survival analysis from diagnosis to death.

Main Results:

  • 17% received radical radiotherapy, 11% with chemotherapy; 20% with stage IIIA underwent surgery, often with adjuvant chemotherapy.
  • 34% received palliative treatment, 36% received no active anti-cancer treatment.
  • 1-year survival was 32.9%, with highest survival in patients receiving chemotherapy and surgery.

Conclusions:

  • Significant gaps exist in delivering optimal multimodality treatment for stage III NSCLC.
  • Less than one-fifth of patients received recommended surgery or radiotherapy with chemotherapy.
  • Improving access to specialists, shared decision-making, and challenging preconceptions can optimize management.