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Related Experiment Video

Updated: Jan 19, 2026

Mechanical Ventilation III: Noninvasive Ventilation
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Noninvasive ventilation during weaning from prolonged mechanical ventilation.

Piero Ceriana1, Stefano Nava2, Michele Vitacca3

  • 1Respiratory Intensive Care Unit and Respiratory Rehabilitation Unit, Istituti Clinici Scientifici Maugeri IRCCS, Istituto Scientifico di Pavia, Italy.

Pulmonology
|September 15, 2019
PubMed
Summary

Non-invasive ventilation (NIV) combined with decannulation is a feasible strategy for patients requiring prolonged mechanical ventilation. This approach shows good one-year survival rates and few complications, facilitating the weaning process.

Keywords:
Non invasive ventilationProlonged weaningRehabilitationRespiratory mechanicsSurvivalTracheostomy decannulation

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Area of Science:

  • Respiratory Medicine
  • Critical Care Medicine
  • Pulmonology

Background:

  • Non-invasive ventilation (NIV) is used for acute weaning but not standardized for prolonged mechanical ventilation.
  • Decannulation protocols for tracheostomized patients on prolonged ventilation are limited.

Purpose of the Study:

  • To evaluate the feasibility and one-year outcomes of a combined NIV and decannulation protocol.
  • To assess survival and complication rates in tracheostomized patients undergoing this protocol.

Main Methods:

  • Prospective data collection from 2005-2018 in a weaning unit.
  • Inclusion criteria: tolerance of 8h unsupported breathing, progressive hypercapnia, good NIV adaptation, decannulation criteria met.
  • Patients were switched from invasive mechanical ventilation (IMV) to NIV, decannulated, discharged on home NIV, and followed for one year.

Main Results:

  • 46 out of 147 eligible patients (35%) were enrolled in the protocol.
  • After a mean stay of 35 days, patients were decannulated and discharged on home NIV.
  • One-year survival rate was 82% (38/46 patients alive), with 37 using NIV effectively.

Conclusions:

  • NIV is feasible for weaning patients from prolonged IMV and aids decannulation.
  • Successful completion of this protocol leads to good survival and low complication rates.