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Slide Preparation Method to Preserve Three-dimensional Chromatin Architecture of Testicular Germ Cells
Published on: January 10, 2014
Somatic Transformation in Metastatic Testicular Germ Cell Tumours - A Different Disease Entity
Anand Sharma1, Constantine Alifrangis2,3, Marina Milic4
1Department of Medical Oncology, Mount Vernon Cancer Centre, Northwood, U.K. anand.sharma3@nhs.net Constantine.alifrangis1@nhs.net.
Background/Aim:
The occurrence of somatic transformation in germ cell tumour (GCT) is rare, with increased incidence in teratomatous tumours. The aim of this study was to understand the clinical outcomes of patients with metastatic GCT with somatic transformation.
Materials And Methods:
A retrospective study was conducted in two tertiary cancer centres in London. Between 1998 and 2016, 30 cases of somatic transformation in GCT treated at the Mount Vernon Cancer Centre and St. Bartholomew's Hospital were identified. The median age at diagnosis was 34 years (range=18-56 years). The histological diagnosis at transformation was rhabdomyosarcoma, sarcomatoid yolk sac, sarcoma (non-specified), clear cell carcinoma, adenocarcinoma and primitive neuro ectodermal tumour (PNET).
Results:
The 5-year survival rate of all patients was 47%, and that of patients with testicular primary (n=26 patients) was 37%.
Conclusion:
Somatic transformation component in testicular GCTs is generally considered to be an adverse prognostic factor, however, a reasonable 5-year overall survival rate (87.5%) was observed in patients who present with this at first diagnosis.
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