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Published on: August 3, 2021
Multifaceted structural magnetic resonance imaging findings in demented patients with pathologically confirmed TDP-43
Keita Sakurai1, Satoru Morimoto2, Takuya Oguri3
1Department of Radiology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan. ksak666@yahoo.co.jp.
Abstract:
This short report clarifies the heterogeneity of structural magnetic resonance imaging (MRI) findings in seven demented patients due to pathologically accumulated TAR DNA-binding protein-43 (TDP-43) protein using visual analyses including visual rating scales (i.e., global cortical atrophy and medial temporal atrophy scales). In addition to the well-known frontotemporal lobar atrophy, structural MRI has revealed multifaceted imaging findings including asymmetric atrophy of the frontoparietal lobe and cerebral peduncle, midbrain atrophy, and localized or diffuse white matter T2 hyperintensity. Understanding of these multifaceted neuroimaging findings is important for the precise antemortem diagnosis of TDP-43 proteinopathy.
Insights
Structural MRI reveals diverse brain changes in dementia caused by TAR DNA-binding protein-43 (TDP-43) proteinopathy. Recognizing these varied neuroimaging findings aids in accurate diagnosis of TDP-43 protein accumulation.
Area of Science:
- Neurology
- Radiology
- Neuroscience
Background:
- Dementia diagnosis relies on identifying underlying pathologies.
- TAR DNA-binding protein-43 (TDP-43) proteinopathy is a common cause of dementia.
- Structural magnetic resonance imaging (MRI) is crucial for neurodegenerative disease assessment.
Purpose of the Study:
- To clarify the heterogeneity of structural MRI findings in patients with TDP-43 proteinopathy.
- To correlate visual MRI analyses with pathological TDP-43 accumulation.
- To enhance understanding of neuroimaging markers for TDP-43 proteinopathy.
Main Methods:
- Visual analysis of structural MRI scans in seven demented patients.
- Utilized visual rating scales for global cortical atrophy and medial temporal atrophy.
- Examined findings beyond typical frontotemporal lobar atrophy.
Main Results:
- Observed multifaceted structural MRI findings, including asymmetric frontoparietal and cerebral peduncle atrophy.
- Identified midbrain atrophy and white matter T2 hyperintensity (localized or diffuse).
- Confirmed heterogeneity in imaging presentation beyond frontotemporal lobar atrophy.
Conclusions:
- Structural MRI demonstrates diverse patterns in TDP-43 proteinopathy.
- Multifaceted neuroimaging findings are key for precise antemortem diagnosis.
- Understanding MRI heterogeneity improves diagnostic accuracy for TDP-43-related dementias.
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