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Related Experiment Video

Updated: Jan 19, 2026

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Cellulose-based injectable hydrogel composite for pH-responsive and controllable drug delivery.

Nusheng Chen1, Hui Wang2, Chen Ling3

  • 1Department of Agricultural & Biological Engineering, University of Florida, PO Box 110570, Gainesville, FL 32611-0570, United States.

Carbohydrate Polymers
|September 16, 2019
PubMed
Summary

Researchers developed injectable, cellulose-based hydrogels with pH-responsive micelles for sustained drug delivery. This biocompatible system offers tunable, stimuli-driven release of hydrophobic drugs, enhancing localized therapeutic effects.

Keywords:
2-(diisopropylamino) ethyl methacrylate (PubChem CID: 28003)Carboxymethylcellulose sodium (PubChem CID: 6328154)CelluloseDoxorubicin (PubChem CID: 31703)Injectable hydrogelNile red (PubChem CID: 65182)Prolonged drug deliverypH-responsive

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Localized drug delivery requires advanced materials for controlled release.
  • Stimuli-responsive hydrogels offer tunable release kinetics.
  • Cellulose derivatives are promising biocompatible materials for biomedical applications.

Purpose of the Study:

  • To construct injectable, cellulose-based hydrogels for localized drug delivery.
  • To embed pH-responsive diblock copolymer micelles within the hydrogel matrix.
  • To achieve prolonged, stimuli-driven, and slow-release functionality.

Main Methods:

  • Modified carboxymethyl cellulose (CMC) polymers (CMC-NH2 and CMC-CHO) were synthesized.
  • pH-responsive poly(ethylene oxide)-block-poly(2-(diisopropylamino) ethyl methacrylate) (PEO-b-PDPA) micelles were prepared via ATRP.
  • An injectable hydrogel composite was formed using Schiff base reaction between CMC-NH2 and CMC-CHO, incorporating PEO-b-PDPA micelles.

Main Results:

  • The synthesized hydrogel system demonstrated tunable, pH-triggered, prolonged, and slow-release profiles for hydrophobic substances (Nile Red, doxorubicin).
  • The hydrogel composite exhibited stable storage moduli.
  • Tunable degradation properties were observed for the cellulose-based double barrier system.

Conclusions:

  • Injectable, cellulose-based hydrogels with embedded pH-responsive micelles provide an effective platform for localized drug delivery.
  • The Schiff base crosslinking method facilitates the creation of a tunable, stimuli-responsive drug delivery system.
  • This novel hydrogel system holds potential for advanced therapeutic applications requiring controlled drug release.