Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Manufacturing Chimeric Antigen Receptor (CAR) T Cells for Adoptive Immunotherapy06:51

Manufacturing Chimeric Antigen Receptor (CAR) T Cells for Adoptive Immunotherapy

15.9K
We describe an approach to reliably generate chimeric antigen receptor (CAR) T cells and test their differentiation and function in vitro and in...
15.9K
High-frequency Ultrasonography Based Early Pregnancy Characterization: A Technique to Study Embryo Implantation and Pregnancy Progression in Pregnant Murine Model04:11

High-frequency Ultrasonography Based Early Pregnancy Characterization: A Technique to Study Embryo Implantation and Pregnancy Progression in Pregnant Murine Model

2.8K
In this video, we demonstrate high-frequency ultrasonography to image embryo implantation sites in a pregnant murine model. This imaging technique successfully detects viable pregnancy and characterizes embryo-implantation sites during early murine...
2.8K
Tumor Immunotherapy01:27

Tumor Immunotherapy

1.8K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.8K
Line Loss01:10

Line Loss

517
The different configurations of source-load connections include wye (star) and delta connections. The relationship between line and phase voltages and currents varies depending on the configuration. When the source is supplying power, it is transmitted through the wires to the load, and during this transmission, some power is absorbed by the wires, leading to line loss.
Line loss impacts power delivery efficiency in a balanced three-phase circuit. The symmetry in such a circuit simplifies the...
517
A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse07:04

A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse

8.8K
Mice are widely used to study gestational biology. However, pregnancy termination is required for such studies which precludes longitudinal investigations and necessitates the use of large numbers of animals. Therefore, we describe a non-invasive technique of high-frequency ultrasonography for early detection and monitoring of post-implantation events in the pregnant mouse.
8.8K
Pregnancy and Nursing Management for Embryo-Transferred and Genetically Modified Rabbits04:29

Pregnancy and Nursing Management for Embryo-Transferred and Genetically Modified Rabbits

1.2K
This protocol describes a pregnancy and feeding management technique for embryo-transferred and genetically modified rabbits, aimed at reducing newborn rabbit mortality and enhancing the preparation efficiency of gene-edited...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chromosomal abnormalities in primary and secondary recurrent miscarriages: significance for PGT-A.

Journal of assisted reproduction and genetics·2025
Same author

Cancer diagnosis among women with recurrent pregnancy loss: a retrospective cohort study.

Reproductive biomedicine online·2021
Same author

Uterine rupture during pregnancy: The URIDA (uterine rupture international data acquisition) study.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2021
Same author

Unexplained repeated pregnancy loss is associated with altered perceptual and brain responses to men's body-odor.

eLife·2020
Same author

Preface: Volume 60.

Best practice & research. Clinical obstetrics & gynaecology·2019
Same author

Enoxaparin (or plus aspirin) for the prevention of recurrent miscarriage: a meta-analysis of randomized controlled studies.

European journal of obstetrics, gynecology, and reproductive biology·2019
Same journal

Occupational exposures and maternal mental health across the perinatal period: a systematic review.

Best practice & research. Clinical obstetrics & gynaecology·2026
Same journal

Essential tips on sample size calculation and biostatistics.

Best practice & research. Clinical obstetrics & gynaecology·2026
Same journal

Non-immune causes of fetal anemia.

Best practice & research. Clinical obstetrics & gynaecology·2026
Same journal

A risk-based classification of late-onset fetal growth disorders according to intrapartum fetal compromise.

Best practice & research. Clinical obstetrics & gynaecology·2026
Same journal

The Cardiac-Fetal-Placental Unit: links between umbilical venous flow and maternal hemodynamics in fetal growth restriction.

Best practice & research. Clinical obstetrics & gynaecology·2026
Same journal

Psychosocial interventions for women who are pregnant following a previous reproductive loss: A scoping review.

Best practice & research. Clinical obstetrics & gynaecology·2026
See all related articles

Related Experiment Video

Updated: Jan 19, 2026

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
06:51

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

15.9K

Immunotherapy for recurrent pregnancy loss.

Howard Carp1

  • 1Department of Obstetrics & Gynecology, Sheba Medical Center, Tel Hashomer, 52621, Israel.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|September 16, 2019
PubMed
Summary
This summary is machine-generated.

Immunotherapy for recurrent miscarriage (RM) improves live birth rates only in selected patients with poor prognosis or immune issues. Careful patient selection and considering spontaneous pregnancy rates are crucial for effective treatment.

Keywords:
FilgrastimIntralipidIntravenous immunoglobulinPaternal leukocyte immunizationRecurrent miscarriage

More Related Videos

High-frequency Ultrasonography Based Early Pregnancy Characterization: A Technique to Study Embryo Implantation and Pregnancy Progression in Pregnant Murine Model
04:11

High-frequency Ultrasonography Based Early Pregnancy Characterization: A Technique to Study Embryo Implantation and Pregnancy Progression in Pregnant Murine Model

2.8K
A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse
07:04

A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse

Published on: October 24, 2017

8.8K

Related Experiment Videos

Last Updated: Jan 19, 2026

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
06:51

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

15.9K
High-frequency Ultrasonography Based Early Pregnancy Characterization: A Technique to Study Embryo Implantation and Pregnancy Progression in Pregnant Murine Model
04:11

High-frequency Ultrasonography Based Early Pregnancy Characterization: A Technique to Study Embryo Implantation and Pregnancy Progression in Pregnant Murine Model

2.8K
A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse
07:04

A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse

Published on: October 24, 2017

8.8K

Area of Science:

  • Reproductive Immunology
  • Obstetrics and Gynecology

Background:

  • Recurrent miscarriage (RM) affects a significant number of women.
  • The efficacy of immunomodulation in RM is debated, with varying results in unselected populations.
  • Immune phenomena are suspected contributors to pregnancy loss in some RM cases.

Purpose of the Study:

  • To review the effectiveness of immunomodulatory agents in recurrent miscarriage.
  • To discuss the role of patient selection in immunotherapy for RM.
  • To explore immune-mediated mechanisms of pregnancy loss and potential therapeutic modulation.

Main Methods:

  • Review of four immunomodulatory agents: paternal leukocyte immunization, intravenous immunoglobulin (IVIg), intralipid, and filgrastim.
  • Analysis of factors confounding treatment outcomes, including embryonic aneuploidy.
  • Consideration of spontaneous live birth prognosis in RM patient populations.

Main Results:

  • Immunotherapy shows efficacy in selected RM populations with poor prognosis or immune markers.
  • Unselected RM populations do not demonstrate improved live birth rates with immunomodulation.
  • Embryonic aneuploidy can mask the true effectiveness of immunotherapy.

Conclusions:

  • Patient selection is critical for successful immunotherapy in recurrent miscarriage.
  • Immune-mediated mechanisms of pregnancy loss warrant further investigation and targeted therapeutic approaches.
  • Future trials must account for spontaneous prognosis and confounding factors like aneuploidy.