Related Experiment Video
Updated: Jan 19, 2026
Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
Published on: May 20, 2020
Yes-Associated Protein Promotes the Development of Condyloma Acuminatum through EGFR Pathway Activation
Zhenghui Yang1, Hao Xiong1, Shanshan Wei1
1Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Objective:
Investigate the role of Yes-associated protein (YAP1) in the development of condyloma acuminatum (CA).
Methods:
We enrolled 30 male patients with CA and 20 healthy individuals as a control group, to compare the YAP1 expression in their tissue samples. Following this, we overexpressed and downregulated YAP1 expression in HaCaT cells to examine the migratory, proliferative, and apoptotic potential of HaCaT cells expressing different levels of YAP1.
Results:
In the CA patient tissue samples, an increase in YAP1 expression can be observed. In vitro,the overexpression of YAP1 was shown to promote the growth and migration of HaCaT cells and to activate epidermal growth factor receptor (EGFR) pathway-associated proteins, while the downregulation of YAP1 inhibited cell growth and migration of these cells.
Conclusions:
YAP1 promotes the growth of keratinocytes in CA through the activation of the EGFR pathway, and it may mediate the development of human papilloma virus-associated diseases.
More Related Videos
Related Concept Videos
15:05Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
09:32Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
08:12Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans
08:15Antagonistic Effect of Jiawei Shengjiang San on a Rat Model of Diabetic Nephropathy: Related to EGFR/MAPK3/1 Signaling Pathway
02:40The Eukaryotic Promoter Region
01:25cAMP-dependent Protein Kinase Pathways