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Involvement of arachidonate-dependent lipid mediators and platelet-activating factor in experimental murine contact
M Csatò1, T Rosenbach, B M Czarnetzki
1Department of Dermatology, University of Münster, FRG.
Skin Pharmacology : the Official Journal of the Skin Pharmacology Society
|January 1, 1988
Abstract:
A 5-lipoxygenase inhibitor (5-LPI) and a platelet-activating factor antagonist (PAF-A) were studied in dinitrofluorobenzene (DNFB)-induced allergic and croton-oil-induced irritant murine contact dermatitis. Both inhibitors, at 1 and 5% concentrations, significantly reduced the ear swelling in allergic dermatitis while irritant dermatitis was far less affected. This suggests that 5-lipoxygenase-dependent mediators and PAF are involved in allergic contact dermatitis and that these mediators play only a minor role in irritant dermatitis.