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Polymicrobial oral biofilm models: simplifying the complex.

Jason L Brown1,2, William Johnston1, Christopher Delaney1

  • 1Oral Sciences Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.

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|September 17, 2019
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Summary
This summary is machine-generated.

Oral biofilm models are crucial for studying oral diseases. This review details the evolution, benefits, and drawbacks of in vitro oral biofilm models for researchers.

Keywords:
biofilmsdental plaquehost–pathogen interactionsoral biofilm modelsoral microbiology

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Area of Science:

  • Oral microbiology
  • Dental research
  • Biofilm science

Background:

  • Oral biofilm models are essential for understanding oral diseases.
  • In vivo models are costly and ethically challenging.
  • In vitro models offer cost-effective and manipulable alternatives.

Purpose of the Study:

  • To review the progression and improvements in oral biofilm models.
  • To discuss the advantages and disadvantages of various models.
  • To highlight the contribution of these models to understanding oral disease.

Main Methods:

  • Literature review of oral biofilm model development.
  • Analysis of in vitro and in vivo model characteristics.
  • Synthesis of findings on model utility in oral research.

Main Results:

  • Oral biofilm models have significantly advanced over the past century.
  • In vitro models provide controlled environments for studying microbial dynamics.
  • These models have enhanced comprehension of oral disease pathogenesis.

Conclusions:

  • Oral biofilm models are indispensable tools in dental research.
  • In vitro models offer a versatile and ethical approach to studying oral health.
  • Continued development of these models will further elucidate oral disease mechanisms.