Related Experiment Video
Updated: Jan 19, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Validating a Quality-of-Life Instrument for Allergic Contact Dermatitis
Nina Botto1, Jodie Raffi1,2, Megha Trivedi3
1From the Department of Dermatology, University of California, San Francisco.
Background:
Contact dermatitis is a prevalent condition that has a significant impact on quality of life (QoL). Although many generic dermatological QoL instruments exist, none were developed by and for patients with allergic contact dermatitis (ACD).
Objective:
The aim of the study was to create and validate a reliable QoL instrument specific for the ACD population.
Methods:
We identified QoL items specific to ACD through a series of qualitative interviews with ACD patients and experts. We created a 17-question survey that queries the patient across the following 3 major domains: symptoms, functioning, and emotions. We used statistical methods to evaluate the reliability and validity of this tool.
Results:
Ninety patients with relevant positive results on patch testing completed the novel ACD instrument and the Skindex-29. This instrument exhibited reliability and validity in individuals with ACD and was more sensitive than the generic tool Skindex-29.
Conclusions:
This novel instrument is the first tool developed specifically to assess the unique impacts of ACD on QoL. Providers can reliably use this index to assess the specific aspects of the disease most problematic for the ACD patient and use this information to more properly inform counseling and management.
Related Concept Videos
08:25Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:02A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Allergic Reactions
10:27Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Reliability and Validity
10:39Qualitative and Quantitative Validation of Tools with Rating Scales Aimed at Assessing the Quality of University Service-Learning
