Related Experiment Video

Updated: Jan 19, 2026

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
09:45

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Published on: August 21, 2019

7.5K

Immune checkpoint blockade in small cell lung cancer

Rebecca Y Tay1, David Heigener2, Martin Reck3

  • 1Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.

Lung Cancer (Amsterdam, Netherlands)
|September 17, 2019
PubMed

Insights

Immune checkpoint inhibitors show therapeutic potential in small cell lung cancer (SCLC). This review examines clinical trial data for anti-PD-1, anti-PD-L1, and anti-CTLA-4 agents in SCLC, alongside biomarker strategies.

Area of Science:

  • Oncology
  • Immunology
  • Clinical Trials

Background:

  • Small cell lung cancer (SCLC) has high immunogenic potential.
  • Therapeutic progress with immune checkpoint agents in SCLC lags behind non-small cell lung cancer.
  • Clinical trials of immune checkpoint inhibitors in SCLC are emerging.

Purpose of the Study:

  • To review available evidence for immune checkpoint blockade in SCLC.
  • To examine current biomarker strategies for SCLC immunotherapy.
  • To provide perspective and interpretation of data for clinical practice.

Main Methods:

  • Systematic review of phase I-III clinical trials.
  • Analysis of data for anti-PD-1, anti-PD-L1, and anti-CTLA-4 agents in SCLC.
  • Evaluation of current biomarker strategies in SCLC immunotherapy.

Main Results:

  • Clinical trial results for immune checkpoint inhibitors in SCLC are now available.
  • Evidence for the efficacy of anti-PD-1, anti-PD-L1, and anti-CTLA-4 agents in SCLC is accumulating.
  • Biomarker strategies are under development to guide SCLC immunotherapy.

Conclusions:

  • Immune checkpoint blockade represents a promising therapeutic avenue for SCLC.
  • Further research and biomarker development are crucial for optimizing SCLC immunotherapy.
  • This review synthesizes current evidence to inform clinical practice in SCLC treatment.
Keywords:
AtezolizumabImmunotherapyIpilimumabNivolumabPembrolizumabSmall cell lung cancer

More Related Videos

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

353
Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung09:57

Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung

Published on: November 16, 2021

7.7K

Related Concept Videos

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines09:45

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

The presence of cancer stem cells have been associated with relapse or poor outcomes after radiotherapy. This manuscript describes the methods to study the radiosensitivity of cancer stem cells in lung cancer cell...
7.5K
Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

This protocol describes an automated, ISO15189-accredited next-generation sequencing workflow for detecting targetable genomic alterations in non-small cell lung cancer (NSCLC) formalin-fixed paraffin-embedded...
353
Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung09:57

Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung

In this study, we present an effective and reproducible protocol to isolate the immune populations of the murine respiratory system. We also provide a method for the identification of all innate and adaptive immune cells that reside in the lungs of healthy mice, using a 9-color-based flow cytometry...
7.7K
Adenocarcinoma Engraftment: A Method to Implant Cancer Cells into the Murine Lungs04:36

Adenocarcinoma Engraftment: A Method to Implant Cancer Cells into the Murine Lungs

This video describes a method to engraft lung adenocarcinoma cells in murine lungs by preconditioning the airways with fibrosis-inducing agent–bleomycin. This method significantly enhances orthotopic engraftment of lung cancer cells into murine...
3.2K
An In Vitro Method to Identify Innate and Adaptive Immune Cells Residing in Murine Lungs05:54

An In Vitro Method to Identify Innate and Adaptive Immune Cells Residing in Murine Lungs

This video demonstrates an in vitro technique to identify immune cells residing in murine lungs. After isolating target immune cells from murine lung tissue, they are surface-labeled using a cocktail of fluorophore-tagged antibodies against specific markers on innate and adaptive immune cells. Additionally, monocytes, macrophages, and dendritic cells are labeled using an intracellular marker. The various immune cell types are then identified using flow...
552
Neuromuscular Junction And Blockade01:29

Neuromuscular Junction And Blockade

The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...
4.8K