Recent developments of nanoparticle-delivered dosage forms for buccal delivery

Area of Science:

• Pharmaceutical Sciences
• Biotechnology
• Materials Science

Background:

• Buccal drug delivery faces challenges in drug permeability and controlled release.
• Nanotechnology offers promising solutions for enhancing buccal formulations.
• Nanoparticle incorporation improves drug delivery efficiency and minimizes systemic side effects.

Purpose of the Study:

• To review advanced concepts and technologies for incorporating nanoparticles into buccal dosage forms.
• To discuss strategies for improving drug delivery and targeting via the buccal mucosa.
• To provide an overview of current nanoparticle-based controlled drug delivery strategies for buccal administration.

Main Methods:

• Literature review of recent advancements in nanoparticle-based buccal drug delivery.
• Classification and discussion of various nanoparticle delivery systems.
• Analysis of strategies for topical and systemic buccal administration using nanoparticles.

Main Results:

• Nanoparticles significantly improve drug permeability and controlled release in buccal formulations.
• Various approaches exist for loading and delivering nanoparticles to the buccal mucosa.
• Nanotechnology enables efficient drug targeting and reduces adverse biological effects.

Conclusions:

• Advanced nanoparticle technologies are crucial for optimizing mucoadhesive buccal formulations.
• Innovative nanoparticle-delivered dosage forms hold significant potential for future clinical applications in buccal drug delivery.
• Further research in this area will drive the development of more effective buccal therapies.