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Clay-based Formulations for Bioavailability Enhancement of Poorly Water-soluble Drugs
Phuong H L Tran1, Thao T D Tran2
1Institute for Innovation in Physical and Mental Health and Clinical Translation, School of Medicine, IMPACT, Deakin University, Geelong, Australia.
Current Drug Metabolism
|June 21, 2021
Summary
This review explores clay-based drug delivery systems for poorly water-soluble medications. It highlights clays
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Nanotechnology
Background:
- Clays are utilized in healthcare products, notably in advanced drug delivery systems.
- Their properties, including high adsorption, surface area, and ion exchange capacity, make them suitable for drug delivery.
- Limited information exists on classifying and discussing clay-based formulations for poorly water-soluble drugs.
Purpose of the Study:
- To review efficient drug delivery systems using clay as the primary excipient.
- To discuss strategies and fabrication methods for incorporating clays into formulations.
- To evaluate hybrid formulations combining clays with other excipients.
Main Methods:
- Literature review of clay-based formulations for drug delivery.
- Analysis of clay properties relevant to drug encapsulation and release.
- Evaluation of formulation strategies and fabrication techniques.
Main Results:
- Clays offer significant potential for delivering poorly water-soluble drugs due to their physicochemical properties.
- Various formulation strategies and fabrication methods are effective for clay-based systems.
- Hybrid formulations show promise for enhanced drug delivery efficacy.
Conclusions:
- Clay-based formulations represent a promising approach for improving the delivery of poorly water-soluble drugs.
- This review provides a fundamental understanding and outlook for applying these systems in pharmaceutical development.
- Further research into clay-based drug delivery systems can lead to novel therapeutic applications.
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