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Encapsulation of Lipid-based Formulations in Porous Carriers for Controlled Drug Delivery
Phuong H L Tran1, Thao T D Tran2
1Deakin University, School of Medicine, IMPACT, Institute for Innovation in Physical and Mental Health and Clinical Translation, Geelong, Australia.
Current Medicinal Chemistry
|April 21, 2021
Summary
This review explores lipid-based formulations encapsulated in porous materials to improve drug delivery. It details methods for creating these solid dosage forms and enhancing drug loading for better bioavailability.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Lipid-based formulations (LBFs) are crucial for enhancing the bioavailability of poorly water-soluble drugs.
- Encapsulating LBFs in porous materials transforms liquid/semisolid formulations into solid dosage forms.
- Porous carriers offer unique structures for improved drug loading and controlled release.
Purpose of the Study:
- To review key strategies for producing porous carriers containing LBFs.
- To discuss methods for enhancing drug encapsulation efficiency within porous structures.
- To outline critical factors affecting tablet formation for these advanced formulations.
Main Methods:
- Literature review of encapsulation techniques for LBFs in porous materials.
- Analysis of methods to optimize drug loading and control release kinetics.
- Examination of critical parameters influencing the development of solid dosage forms.
Main Results:
- Identification of diverse strategies for encapsulating LBFs within porous carriers.
- Discussion of techniques to maximize drug encapsulation efficiency.
- Outline of key factors influencing the successful formation of tablets from these formulations.
Conclusions:
- Encapsulating LBFs in porous materials is a viable strategy for developing advanced drug delivery systems.
- Optimizing encapsulation methods and understanding tablet formation are crucial for clinical translation.
- This review provides a comprehensive summary of technical methods for LBF-porous material formulation development.
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