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Related Concept Videos

3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells06:17

3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells

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A reproducible method is presented to generate 3D myocardial tissues combining melt electrospinning writing (MEW) polycaprolactone (PCL) scaffolds and fibrin hydrogels with hiPSC-derived cardiomyocytes and fibroblasts. This technique offers precise control over scaffold architecture and can be applied in preclinical drug testing and cardiac disease...
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Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering07:14

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Novel nanocomposites of graphene nanoribbons and hydroxyapatite nanoparticles were prepared using solution-phase synthesis. These hybrids when employed in bioactive scaffolds can exhibit potential applications in tissue engineering and bone...
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This protocol serves as a comprehensive guideline to fabricate scaffolds via electrospinning with polymer melts in a direct writing mode. We systematically outline the process and define the appropriate parameter settings for achieving targeted scaffold...
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Presented here is a simple-to-use, core/shell, three-dimensional bioprinting set-up for one-step fabrication of hollow scaffolds, suitable for tissue engineering of vascular and other tubular...
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The aim of this study was to mimic the native three layered architecture of the arterial wall. To accomplish this, electrospinning was employed with the use of a 3-1 (input-output) nozzle and blends of polycaprolactone, elastin, and...
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Related Experiment Video

Updated: Jan 19, 2026

3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells
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3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells

Published on: March 28, 2025

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Flexible Polycaprolactone and Polycaprolactone/Graphene Scaffolds for Tissue Engineering.

Stanislav Evlashin1, Pavel Dyakonov2,3, Mikhail Tarkhov4

  • 1Center for Design Manufacturing & Materials, Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, bld. 1, 121205 Moscow, Russia. S.Evlashin@skoltech.ru.

Materials (Basel, Switzerland)
|September 19, 2019
PubMed
Summary

This study explores composite polycaprolactone scaffolds for bone tissue engineering. Graphene oxide enhances scaffold properties, showing promise for biocompatible bone regeneration in future medical trials.

Keywords:
flexible compositegraphene oxidepolycaprolactonescaffoldsupercritical foaming

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Last Updated: Jan 19, 2026

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Bone defects pose significant challenges in patient recovery.
  • Advanced biomaterials are crucial for developing effective bone tissue engineering scaffolds.
  • Polycaprolactone (PCL) is a versatile polymer for biomedical applications.

Purpose of the Study:

  • To investigate the supercritical foaming of composite polycaprolactone scaffolds.
  • To evaluate the impact of graphene oxide (GO) and reduced graphene oxide (rGO) on scaffold properties.
  • To assess the biocompatibility and cell interactions of the developed bone scaffolds.

Main Methods:

  • Supercritical fluid foaming technique was employed for scaffold fabrication.
  • Structural and mechanical properties of PCL/GO and PCL/rGO composite scaffolds were analyzed.
  • Co-culturing and live/dead assays were performed to evaluate cell viability and behavior.

Main Results:

  • The addition of GO and rGO influenced the foaming parameters and scaffold microstructure.
  • Composite scaffolds exhibited desirable mechanical flexibility and endurance.
  • Scaffolds demonstrated excellent biocompatibility, supporting cell proliferation and varied surface interactions.

Conclusions:

  • Composite polycaprolactone foams incorporating graphene oxide show significant potential for bone tissue engineering.
  • These scaffolds are promising candidates for further in vivo investigations and clinical applications.
  • The study highlights the tunable properties of PCL-based scaffolds for enhanced bone regeneration.