Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

4.1K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biocidal Elastic Films Based on Cod Collagen, Pectin, and PMMA Copolymers: Effectiveness in Healing Burn Surfaces in Small Animals.

Polymers·2026
Same author

Determinants of MSC immunophenotypic plasticity: From canonical priming to emerging strategies for cancer and inflammatory therapies.

Biochimica et biophysica acta. Reviews on cancer·2026
Same author

Tailoring Spin-Orbit Interaction in High Harmonic Generation via Geometric Phase.

Physical review letters·2026
Same author

Impact of stem cell therapy on brain metabolic profile in cerebral palsy assessed by magnetic resonance spectroscopy in a randomized clinical trial.

Scientific reports·2026
Same author

Targeting PCSK9, APOB, and CETP at the Transcriptome Level by hsa-miR-30b-3p Reduces LDL-Associated Protein in Huh-7 Cells.

Molecular biology reports·2026
Same author

Mechanical signature of cancer cells: From cytoskeletal alterations to cell rheology.

Progress in biophysics and molecular biology·2026
Same journal

A Coumarin-Based Probe for Sequential ON-OFF-ON Detection of Cu<sup>2+</sup> and Biothiols: Naked-Eye Detection, Smartphone RGB Readout and In Vivo Imaging.

Biosensors·2026
Same journal

Electropolymerized Molecularly Imprinted Polymers Supported on Carbon-Based Materials for (Bio)sensing: Direct and Indirect Detection Strategies.

Biosensors·2026
Same journal

Progress in (Photo)electrochemical Biosensors for the Detection of Amyloid-Beta Oligomer.

Biosensors·2026
Same journal

Design and Simulation of Lamotrigine Intermittent Release from a Subcutaneous Implant with an Enzymatic Biosensor Based on Clinical Data.

Biosensors·2026
Same journal

Prediction of Chronic Kidney Disease Based on Simulated Serum Analysis by Vibrational Spectroscopy.

Biosensors·2026
Same journal

AI/ML-Assisted SERS Biosensing for Biomolecular Detection: From Direct Spectral Response to Integrated Diagnostic Systems.

Biosensors·2026
See all related articles
  1. Home
  3. Liver-on-a-chip: Searching For A Balance Between Biomimetics And Functionality.
  1. Home
  3. Liver-on-a-chip: Searching For A Balance Between Biomimetics And Functionality.

Related Experiment Video

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
10:05

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

32.0K

Liver-on-a-Chip: Searching for a Balance Between Biomimetics and Functionality.

Anton Murashko1, Daniil Golubchikov1, Olga Smirnova1

  • 1Institute for Regenerative Medicine, Sechenov University, 119435 Moscow, Russia.

Biosensors
|April 27, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Liver-on-a-chip (LOC) technology offers a promising alternative to animal models for drug development. Future LOC designs must balance complexity and functionality for market viability.

Keywords:
drug testingliverliver-on-a-chipmicrofluidicsmicrophysiology system

More Related Videos

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
10:25

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

13.1K
Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
06:30

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

4.1K

Related Experiment Videos

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
10:05

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

32.0K
"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
10:25

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

13.1K
Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
06:30

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

4.1K

Area of Science:

  • Biomedical Engineering
  • Drug Discovery
  • Toxicology

Background:

  • Animal models often fail in predicting drug efficacy and safety due to species-specific differences.
  • Organ-on-a-chip (OOC) systems, especially liver-on-a-chip (LOC), aim to mimic human physiology at the microscale.
  • LOC technology presents a potential solution to improve preclinical drug assessment.

Purpose of the Study:

  • To review and discuss the architectural design and validation of liver-on-a-chip systems.
  • To identify trends in balancing biomimetic complexity with functional performance in LOC devices.
  • To explore the future direction of LOC technology for drug development.

Main Methods:

  • Literature review of existing liver-on-a-chip models.
  • Classification of LOC designs based on configuration complexity into five groups: flat one-channel, flat two-channel, vertically stacked multilayered, hexagonal-patterned, and multi-well chips.
  • Analysis of the trade-offs between architectural complexity and practical functionality.

    • Main Results:

    • LOC designs vary significantly in complexity, categorized into five main types.
    • Increasing architectural complexity aims to better recapitulate liver histology and function.
    • Industrial preferences lean towards simpler, more flexible LOC designs for scalability.

    Conclusions:

    • Future liver-on-a-chip designs need to prioritize standardization and sustainability.
    • Simplifying certain liver characteristics in LOCs may be necessary for market adoption.
    • Optimized LOC designs can facilitate integration into clinical drug development pipelines.