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Biocidal Elastic Films Based on Cod Collagen, Pectin, and PMMA Copolymers: Effectiveness in Healing Burn Surfaces in
Veronika Prodaevich1, Anna Soloveva1, Petr Peretyagin1
1The Research Institute for Chemistry, Lobachevsky State University of Nizhny Novgorod, pr. Gagarina 23, 603950 Nizhny Novgorod, Russia.
Polymers
|June 12, 2026
Summary
New 3D matrix films made from cod collagen (CC), pectin, and methyl methacrylate (PMMA) show promise as advanced wound dressings. These biocompatible films promote rapid wound healing and exhibit antibacterial properties, paving the way for clinical trials.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Wound Healing Research
Background:
- Developing effective wound dressings is crucial for infection prevention and accelerated healing.
- Existing dressings often lack optimal mechanical properties, biocompatibility, or antibacterial activity.
- Cod collagen (CC), pectin, and methyl methacrylate (PMMA) offer a versatile base for novel biomaterials.
Purpose of the Study:
- To synthesize and characterize 3D matrix films for wound dressings using a copolymer of cod collagen (CC), pectin, and methyl methacrylate (PMMA).
- To evaluate the physical, mechanical, and antibacterial properties of the developed films.
- To assess the in vivo efficacy of the films in promoting wound healing.
Main Methods:
- Photocatalytic synthesis of CC-PMMA-pectin hydrogels using RbTe1.5W0.5O6 and glycerol as a plasticizer.
- Characterization via elemental analysis and electron microscopy.
- Assessment of mechanical properties (tensile strength, elongation at break) and antibacterial resistance.
- In vivo wound healing tests on rat models.
Main Results:
- Transparent, homogeneous, elastic, and easily removable plasticized films (CC-PMMA-pectin-glycerol) were successfully obtained.
- Increased polymer concentration enhanced tensile strength (0.6 to 0.9 MPa) and elongation at break (61% to 76%).
- Films demonstrated significant resistance to bacterial action and achieved complete wound closure in rats by day 28.
Conclusions:
- The developed CC-PMMA-pectin-glycerol films possess favorable physical, mechanical, and antibacterial properties suitable for wound dressing applications.
- The films exhibited high efficiency in promoting wound healing in vivo.
- These findings support the further investigation of these novel films in clinical trials for advanced wound management.
