Integrating radiomics into clinical trial design

Area of Science:

• Radiology
• Medical Imaging
• Oncology

Background:

• Radiomics extracts quantitative features from radiographic images to describe tumor phenotypes.
• It enables non-invasive examination of disease heterogeneity, impacting clinical trials and patient care.

Purpose of the Study:

• To review how radiomics can address challenges in clinical randomized control trials.
• To discuss difficulties in integrating robust radiomics analysis into trial design.

Main Methods:

• The review discusses the radiomics process, including image acquisition, reconstruction, segmentation, feature extraction, and computational analysis.
• Emphasis is placed on the need for standardization at each step.

Main Results:

• Standardization is essential for successful incorporation of radiomics into clinical trials.
• Addressing challenges in standardization can unlock the potential of radiomics.

Conclusions:

• Radiomics holds significant potential for clinical trials and patient care.
• Robust and repeatable radiomics analysis requires extensive standardization across all stages.