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Updated: Jan 19, 2026

In Vitro Assay to Study Tumor-macrophage Interaction
Published on: August 1, 2019
Cabozantinib and apixaban: an hitherto unreported interaction
Daniele Santini1, Fabrizio Citarella1, Bruno Vincenzi1
1Department of Oncology, Campus Bio-Medico University, via Alvaro del Portillo 200, 00128 Rome, Italy.
Abstract:
The use of direct oral anticoagulant in cancer patients is an emerging issue, which seems to be an alternative to low molecular weight heparin. Every year several new drugs are approved as anticancer treatment with possible drug-drug interaction with other drugs such as oral anticoagulant. We describe, for the first time, a case of neutropenia and thrombocytopenia in a patient in treatment with cabozantinib, a novel anticancer treatment used in metastatic renal cell carcinoma, and apixaban with promptly resumption of the toxicity after the interruption of cabozantinib. This case suggest a possible interaction between these two pharmaceutical agents, which merit caution considering the spreading of the two drugs.
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