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Updated: Jan 19, 2026
15:33
Simple and Efficient Technique for the Preparation of Testicular Cell Suspensions
Published on: August 4, 2013
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Testicular Regression Syndrome: a case report.
Christiana de Freitas Vinhas1, Aloísio Felipe-Silva2, Ricardo Frank Coelho da Rocha3
1Department of Pathology - Faculdade de Medicina - Universidade de São Paulo, São Paulo/SP - Brazil.
Autopsy & Case Reports
|September 19, 2019
Summary
Testicular Regression Syndrome (TRS) is a condition where testes are absent or underdeveloped in 46XY individuals. Histological analysis confirmed TRS in a 7-year-old boy initially diagnosed with cryptorchidism.
Area of Science:
- Pediatric Endocrinology
- Developmental Biology
- Surgical Pathology
Background:
- Testicular Regression Syndrome (TRS) affects 46XY individuals with normal external genitalia, presenting as absent or incompletely developed testes.
- TRS prevalence is estimated between 3-20% in cases initially diagnosed as cryptorchidism.
Observation:
- A 7-year-old boy presented with a clinical diagnosis of cryptorchidism, necessitating surgical exploration.
- During surgery, no identifiable testicular structure was found, and presumed testicular remnants were collected for analysis.
Findings:
- Histological examination of the presumed remnants revealed a fibrovascular nodule, spermatic cord structures, and calcification.
- These histological findings definitively supported a diagnosis of Testicular Regression Syndrome.
Implications:
- This case highlights the importance of histological analysis in differentiating TRS from other conditions presenting as cryptorchidism.
- Accurate diagnosis of TRS is crucial for appropriate patient management and genetic counseling.
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