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Updated: Jan 19, 2026

Irritable Bowel Syndrome I: Introduction
01:17

Irritable Bowel Syndrome I: Introduction

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Blastocystis ST-1 is associated with Irritable Bowel Syndrome-diarrhoea (IBS-D) in Indonesian adolescences

Yudianita Kesuma1,2, Agus Firmansyah3, Saptawati Bardosono4

  • 1Department of Pediatrics, Faculty of Medicine, Universitas Sriwijaya and Moh. Hoesin Hospital, Palembang, Indonesia.

Parasite Epidemiology and Control
|September 19, 2019
PubMed

Insights

Blastocystis infection, particularly subtype ST-1, is a significant risk factor for adolescent Irritable Bowel Syndrome with Diarrhea (IBS-D). This study identifies key risk factors and links Blastocystis to IBS-D pathogenicity.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Pediatric Health

Background:

  • Irritable Bowel Syndrome (IBS) is a common functional gastrointestinal disorder in adolescents, presenting with diverse symptoms.
  • Blastocystis is a prevalent intestinal protozoan, but its role in IBS pathogenesis remains debated.

Purpose of the Study:

  • To identify risk factors associated with IBS in adolescents.
  • To investigate the association between IBS subtypes and Blastocystis infection, including its subtypes.
  • To analyze the pathogenicity of Blastocystis in the context of IBS.

Main Methods:

  • A cross-sectional study involving 454 senior high school students using Rome III Criteria for IBS diagnosis.
  • Risk factors and IBS types were assessed via questionnaires.
  • Blastocystis infection and subtypes were identified using microscopy, culture, PCR, 18S rRNA sequencing, and phylogenetic analysis.

Main Results:

  • IBS prevalence was 30.2%, with IBS-Diarrhea (IBS-D) being the most common subtype.
  • Major IBS risk factors included family history, abuse, bullying, and female gender.
  • Blastocystis subtype ST-1 showed a significant association with IBS-D (OR 2.9).

Conclusions:

  • Adolescent Blastocystis infection is identified as a risk factor for developing IBS-D.
  • Blastocystis subtype ST-1 is suggested to be a pathogenic subtype contributing to IBS-D.
Abstract

Keywords:
DiarrhoeaIntestinal protozoaIrritable bowel syndromeRisk factors

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