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Published on: March 20, 2015
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Size-induced segregation during die filling.
A Zakhvatayeva1, C Hare1, C Y Wu1
1Department of Chemical and Process Engineering, University of Surrey, Guildford GU2 7XH, UK.
International Journal of Pharmaceutics: X
|September 19, 2019
Summary
Particle size segregation in pharmaceutical blends was studied during die filling. Suction filling at low velocity minimized segregation, while gravity filling showed higher tendencies due to air drag and cascading effects.
Area of Science:
- Pharmaceutical Science
- Powder Technology
- Materials Science
Background:
- Particle size distribution significantly impacts powder blend uniformity.
- Segregation during die filling can compromise pharmaceutical product quality and efficacy.
- Understanding segregation mechanisms is crucial for robust pharmaceutical manufacturing processes.
Purpose of the Study:
- To investigate particle size-induced segregation in binary pharmaceutical blends during die filling.
- To evaluate the influence of filling methods (gravity vs. suction) and velocities on segregation.
- To determine the primary mechanisms driving segregation in pharmaceutical powder blends.
Main Methods:
- Binary blends of acetylsalicylic acid (coarse) and mannitol (fine) were prepared.
- Die filling was performed using gravity and suction methods at varying velocities.
- Coarse component concentration was measured using UV-Visible spectrophotometry.
- Segregation Index (SI) was calculated to quantify blend uniformity.
Main Results:
- High segregation tendency was observed during low-velocity gravity filling (air drag) and high-velocity gravity filling (multi-step filling).
- Suction filling at low velocity exhibited the lowest segregation tendency.
- Horizontal segregation predominantly occurred in the upper die layers via cascading mechanisms.
Conclusions:
- Filling method and velocity are critical parameters influencing particle segregation in pharmaceutical blends.
- Suction filling offers a potentially more uniform powder deposition compared to gravity filling.
- Segregation mechanisms, particularly particle cascading, must be considered during die filling optimization.
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