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Updated: Jan 19, 2026
Monitoring Colony-level Effects of Sublethal Pesticide Exposure on Honey Bees
Published on: November 15, 2017
Bee honey protects astrocytes against oxidative stress: A preliminary in vitro investigation
Amira Mohammed Ali1,2, Hiroshi Kunugi1
1Department of Mental Disorder Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, Tokyo, Japan.
Aim:
Bee honey is widely used as a bioactive food to improve general health and produce therapeutic benefits in various physical disorders. It also improves cognitive and mood-related behaviors and symptoms in mice and humans. Still, its direct effect on brain cells is unclear. Here, we examined the effect of whole honey on the survival of astrocytes exposed to oxidative stress.
Methods:
Cultured cortical astrocytes were treated with honey (0.1%, 0.3%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 3%, and 5% [v/v]) for 24 hours followed by H2 O2 (100 μmol/L) for 3 hours. Cellular viability was assessed with MTT assay.
Results:
Honey prevented cellular death in a dose-dependent manner compared with H2 O2- treated cells. Honey at 1% concentration had the most significant effect (P = .015).
Conclusion:
Bee honey exerts a neuroprotective effect through its antioxidant activity.
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